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World Nutrition Center
Oral L-citrulline supplementation enhances cycling time trial performance in healthy
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<blockquote data-quote="WNC2" data-source="post: 5746650" data-attributes="member: 12902"><p>Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.</p><p></p><p><strong>Abstract</strong></p><p></p><p><strong>Background</strong></p><p><strong></strong>Many human studies report that nitric oxide (NO) improves sport performance. This is because NO is a potential modulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. L-Citrulline is an amino acid present in the body and is a potent endogenous precursor of L-arginine, which is a substrate for NO synthase. Here, we investigated the effect of oral L-citrulline supplementation on cycling time trial performance in humans.</p><p></p><p><strong>Methods</strong></p><p>A double-blind randomized placebo-controlled 2-way crossover study was employed. Twenty-two trained males consumed 2.4 g/day of L-citrulline or placebo orally for 7 days. On Day 8 they took 2.4 g of L-citrulline or placebo 1 h before a 4-km cycling time trial. Time taken to complete the 4 km cycle, along with power output/VO2 ratio (PO/VO2), plasma nitrite and nitrate (NOx) and amino acid levels, and visual analog scale (VAS) scores, was evaluated.</p><p></p><p><strong>Results</strong></p><p>L-Citrulline supplementation significantly increased plasma L-arginine levels and reduced completion time by 1.5 % (p&#8201;<&#8201;0.05) compared with placebo. Moreover, L-citrulline significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise.</p><p></p><p><strong>Conclusions</strong></p><p><strong><span style="color: Red">Oral L-citrulline supplementation reduced the time take to complete a cycle ergometer exercise trial.</span></strong></p><p></p><p>Takashi Suzuki, Masahiko Morita, Yoshinori Kobayashi and Ayako KamimuraEmail author</p><p>Journal of the International Society of Sports Nutrition201613:6</p><p>DOI: 10.1186/s12970-016-0117-z© Suzuki et al. 2016</p><p>Received: 11 September 2015Accepted: 12 February 2016Published: 19 February 2016</p><p></p><p><a href="https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0117-z" target="_blank">Studio completo qui.</a></p></blockquote><p></p>
[QUOTE="WNC2, post: 5746650, member: 12902"] Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. [B]Abstract[/B] [B]Background [/B]Many human studies report that nitric oxide (NO) improves sport performance. This is because NO is a potential modulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. L-Citrulline is an amino acid present in the body and is a potent endogenous precursor of L-arginine, which is a substrate for NO synthase. Here, we investigated the effect of oral L-citrulline supplementation on cycling time trial performance in humans. [B]Methods[/B] A double-blind randomized placebo-controlled 2-way crossover study was employed. Twenty-two trained males consumed 2.4 g/day of L-citrulline or placebo orally for 7 days. On Day 8 they took 2.4 g of L-citrulline or placebo 1 h before a 4-km cycling time trial. Time taken to complete the 4 km cycle, along with power output/VO2 ratio (PO/VO2), plasma nitrite and nitrate (NOx) and amino acid levels, and visual analog scale (VAS) scores, was evaluated. [B]Results[/B] L-Citrulline supplementation significantly increased plasma L-arginine levels and reduced completion time by 1.5 % (p < 0.05) compared with placebo. Moreover, L-citrulline significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise. [B]Conclusions[/B] [B][COLOR="Red"]Oral L-citrulline supplementation reduced the time take to complete a cycle ergometer exercise trial.[/COLOR][/B] Takashi Suzuki, Masahiko Morita, Yoshinori Kobayashi and Ayako KamimuraEmail author Journal of the International Society of Sports Nutrition201613:6 DOI: 10.1186/s12970-016-0117-z© Suzuki et al. 2016 Received: 11 September 2015Accepted: 12 February 2016Published: 19 February 2016 [URL="https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0117-z"]Studio completo qui.[/URL] [/QUOTE]
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Oral L-citrulline supplementation enhances cycling time trial performance in healthy
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